黎凯教授缪刺法联合弥可保穴位注射治疗周围性面瘫后遗症

黎凯教授认为,面瘫后遗症发生或由于病情较重,或由于治疗不当,日久导致气虚血瘀,瘀阻脉络,弛缓不收而致。病机的关键在于血瘀,治宜补气活血,用缪刺法(留针20～30min,隔日1次,10次为1疗程)化瘀通络联合弥可保穴位注射(隔日1次,10次为1疗程。疗程间休息3日)。重视以补法为主,切忌泻法,免损伤正气。治疗期间嘱患者不再做热敷、运动患侧,防过度引起面瘫并发症;注意防寒,少去人较多的场所,以防感冒;治疗期间,少看电视、电脑等,减少对患侧刺激。     

Treatment of 56 Cases of Pain of Supra-orbital Bone by Puncturing Siguan Acupoints

Pain of supra-orbital bone is very common in clinic The author achieved significant effect in treating 56 cases of pain of supra-orbital bone by puncturing Siguan （four gates） points. The report is as follows.     

A study of proliferative markers and tumor suppressor gene proteins in different grades of ependymomas

Ependymomas are CNS tumors that originate from the spinal canal and walls of the ventricular system. Considerable controversy continues to exist with regard to their prognostic factors; age and extent of resection are the only statistically significant prognostic factors yet identified. The authors report a retrospective study of a homogenous population of 119 patients harbouring ependymomas between 1991 and 2002. All clinico‐radiological and follow‐up data were analyzed and a pathologic review was performed by two pathologists. Immunohistochemical staining for MIB‐1, Topo IIα, p53 and MDM2 was performed. Histopathologic grades show relationship with MIB1 and Topo IIα labelling indices and cut‐off values of 5% can differentiate between anaplastic and lower grades. p53 and MDM2 proteins expression are not common in ependymomas; however, they are seen in higher grades only and may be involved in the tumor progression.     

李素云教授治疗支气管扩张经验

目的：介绍李素云教授辨证论治支气管扩张的临床经验。方法：从病因病机、治则治法、分期施治、内外结合、典型病例等方面对其辨治经验进行了总结。结果：李教授认为支气管扩张病机气虚为本,痰瘀互结为标,临床施治应补肺益气、祛痰化瘀,权衡标本主次之变化,止血是其治疗重点,临床施治多从急性发作期和缓解期分期论治,灵活化裁。并注重外治法和中医传统疗法在临床施治中的应用,内外结合,临床疗效显著。结论：李教授认为支气管扩张是一种反复发作、缠绵难愈的难治性疾病,无论急性发作期还是缓解期,肺虚均是其发病的根本原因。临床采用中医分期施治,标本兼顾,气血同治,内外合治,取得了较好的临床疗效。     

Medulloblastomas: a correlative study of MIB-1 proliferation index along with expression of c-Myc,ERBB2, and anti-apoptotic proteins along with histological typing and clinical outcome

Background  Medulloblastoma (MB) is the most common pediatric brain tumor. It is however rare in adults. The genetic and protein expression profile of medulloblastoma is complex, which is worthwhile in terms of prognostication and development or selection of targeted therapy. Aims and objectives  The aims and objectives to correlate the MIB-1 proliferation index and protein expression profiles of c-Myc, ERBB2, and anti-apoptotic proteins (Bcl2 and Bcl-xL) in tumor cells with histological subtypes and clinical outcome. Methods and material  In 50 cases, histopathological subtyping was done, and protein expression profiling by immunohistochemical technique was performed by stains for MIB-1, Bcl2, Bcl-xL, c-Myc, and ERBB2 in 30 cases. The findings were correlated with histological types and patient’s average follow-up data. Results  Histological subtypes were similar to that described in literatures. The average expression of Bcl2, Bcl-xL, MIB-1, c-Myc, and ERBB2 were as follows: 50.38%, 38.18%, 59.03%, 46.16%, and 59.62%, respectively. Bcl2 expression showed statistically significant correlation with progress-free survival (PFS) [p = 0.046], while ERBB2 and MIB-1 showed a trend of higher expression in progressive disease. The protein expression pattern did not correlate with histological subtypes. Conclusion  Though Bcl-2, ERBB2, and MIB-1 LI came out to be potential markers of aggressive behavior, c-Myc did not correlate with PFS in MB.     

李鼎教授对奇经八脉的认识

李鼎教授对督脉、任脉、冲脉、带脉、维脉、跷脉等奇经八脉理论及英与正经的关系等进行了深入的研究,纠正了古代医家对督脉"合篡间,绕篡后"、冲脉循行等错误的理解,对督脉循行、任督经气运行的方向等不同认识进一步分析,加以整理,提出营气的运行方向,督脉是从上而下,任脉则是从下而上等,使奇经八脉理论更加完备,对后世奇经八脉的研究有重要的指导意义.     

Current applications of molecular imaging and luminescence-based techniques in traditional Chinese medicine

Ethnopharmacological relevance

Traditional Chinese medicine (TCM), which is fundamentally different from Western medicine, has been widely investigated using various approaches. Cellular- or molecular-based imaging has been used to investigate and illuminate the various challenges identified and progress made using therapeutic methods in TCM. Insight into the processes of TCM at the cellular and molecular changes and the ability to image these processes will enhance our understanding of various diseases of TCM and will provide new tools to diagnose and treat patients.

Materials and methods

Various TCM therapies including herbs and formulations, acupuncture and moxibustion, massage, Gua Sha, and diet therapy have been analyzed using positron emission tomography, single photon emission computed tomography, functional magnetic resonance imaging and ultrasound and optical imaging. These imaging tools have kept pace with developments in molecular biology, nuclear medicine, and computer technology.

Results

We provide an overview of recent developments in demystifying ancient knowledge - like the power of energy flow and blood flow meridians, and serial naturopathies - which are essential to visually and vividly recognize the body using modern technology.

Conclusions

In TCM, treatment can be individualized in a holistic or systematic view that is consistent with molecular imaging technologies. Future studies might include using molecular imaging in conjunction with TCM to easily diagnose or monitor patients naturally and noninvasively.     

电针曲池、足三里穴对脑缺血再灌注损伤大鼠神经功能缺损的影响

目的：研究电针曲池、足三里穴对脑缺血再灌注损伤大鼠神经功能缺损的影响。方法：Wistar大鼠随机分为5组：正常组、假手术组、模型组、电针非经穴组和电针经穴组,各组再随机分成1d．3d、7d三个时间点。采用改良线栓法制备大鼠大脑中动脉闭塞（MCAO）再灌注模型,应用Zea—Longa的4分制评分法观察各组大鼠在各时间点神经功能缺损评分的变化。结果：随着缺血再灌注时间的延长,模型组大鼠神经功能缺损有不同程度的自愈趋势;电针经穴组可明显降低脑缺血再灌注损伤大鼠神经功能缺损评分,与电针非经穴组和模型组在3d、7d时间点比较均有显著性差异（P〈0．05）。结论：电针曲池、足三里穴对脑缺血再灌注损伤大鼠神经功能缺损具有相对特异性的调节作用。     

神经上皮组织起源的脑肿瘤中连接蛋白的表达

目的　探讨连接蛋白 (Cx) 43、3 2在神经上皮组织起源的脑肿瘤中表达及其与肿瘤的病理类型、恶性程度的关系。方法　利用Cx43、Cx3 2和Ki 67单抗或多抗对 8例正常脑组织、5 0例神经上皮组织起源的脑肿瘤和 4个恶性脑瘤体外细胞系进行免疫组化检测。结果　神经上皮组织起源的脑肿瘤中Cx表达阳性率为 5 4% ,Cx3 2仅在低恶度少枝胶质细胞瘤中表达 ,Cx43表达随WHO分级升高而下降 ;与Ki 67标记指数 (LI)呈负相关。表达缺失多见于高Ki 67LI者。结论　神经上皮组织起源的脑肿瘤中CX 表达可下降或缺失 ,Cx43表达与肿瘤的病理类型及恶性程度密切相关     

补中益气法学术源流、传承及当代应用

补中益气法是临床常用的治法之一.《黄帝内经》《难经》阐述了中气不足的主要临床表现,并总结出劳者温之损者益之的治疗原则.《伤寒杂病论》《医学启源》为补中益气法的用药提供了依据.后世医家传承应用本法,多有创新.如李东垣用补中益气常兼顾升阳、理气、泻火、除湿、和血、养阴等加减变法,罗天益擅用灸法,王好古用以治疗外阳内...